I got really claustrophobic with the default camera and fiddled with it a bit to get 1080p rendering working almost perfectly. I also disabled hud scaling because it looks awful.
The hud needs automatic repositioning but the biggest issue left is to change the distance peds and cars start appearing when running around. When driving the distance is altered and they spawn quite a bit earlier so it's probably easily tweakable as well. It's very playable, though.
Yeah it's glitching a little in the bottom, probably fixable. All 2D elements, including subtitles and the talking head would in this setup be constrained in the 640x480 area in the top left corner. It should be easy to reposition them and possibly configure custom scaling factor (2x would probably look nice in 1080p). The dynamic gameplay elements I'm worried about how to make them work from farther away.
If this works out the modifications can be incorporated to vike's patch if wanted.